PGS & NGS- Gender Choice

When a sperm and egg combine to produce an embryo with the wrong number of chromosomes, the embryo will usually fail to establish a pregnancy or miscarry.This is one of the major causes of miscarriage in IVF or natural conception.

Pre-Implantation Genetic Screening (PGS) and Next Generation Sequencing (NGS) are genetic tests that significantly improve pregnancy rates by up to 68% and also identify gender. They work by detecting small amounts of missing or extra genetic material (DNA) known as ‘copy number variants’. PGS is able to detect small copy number variants that were previously not detectable by methods such as PGD. The test is performed by amplifying embryo cells to identify the amount of DNA they contain and examining all chromosome pairs for abnormalities.

The PGS Procedure

Similar to standard IVF treatment, eggs are retrieved and fertilised. Five days later at the blastocyst stage, a small number of cells are removed from the growing embryos and PGS is used to check for any significant abnormalities present in the chromosomes. In effect it scans the DNA packed in the cells’ chromosomes for any abnormalities.

Based on the information gained, it is possible to ensure that only embryos with the correct number of chromosomes are transferred, greatly improving pregnancy rates- by up to 68%.

Studies by Oxford University have shown genetic screening has an accuracy rate of greater than 95% for detecting abnormal embryos.

Gender Choice is available

You can now choose the gender of your child using our PGS services. Contact us for more details.

Why PGS is superior

IVF treatment has two problems. Firstly, many of the embryos produced in a typical IVF cycle have the wrong number of chromosomes or significant amounts of DNA missing or duplicated. Secondly, the usual assessments performed in an IVF clinic, which involve looking at embryos under a microscope to see how they are growing, cannot distinguish embryos with lethal chromosome problems from those that are healthy.

PGS and NGS allow the embryologist to identify which embryos have the correct number of chromosomes. These embryos have the best chance of producing a baby and the lowest chances of miscarriage.

Our affiliated clinics are amongst the few in Asia to be able to offer PGS and NGS in-house.

For more information about PGS or Gender Choice please contact Cathie.